Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 5 Articles
The present work was carried out to prepare and evaluate floating microspheres of the model antipsychotic drug, risperidone, using various viscosity grades of polymers such as polyvinylpyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC). Floating microspheres were prepared by emulsion solvent diffusion technique using Eudragit S100, compritol 888 ATO and hydroxypropyl methyl cellulose (HPMC E15 and E50) or polyvinylpyrrolidone (PVP K25, K30 and K90). The prepared formulations were examined by scanning electron microscope and were also characterized for their yield value, drug loading, floating behavior as well as in-vitro drug release pattern. Floating microspheres were found to be hollow spherical with smooth surfaces. Using high viscosity grade of HPMC in formulating floating microspheres demonstrated more pronounced increase in the microsphere yield and drug loading values and resulted in more sustained drug release as well as high buoyancy percentage value at the end of 12 hr. The formula containing 5% risperidone, 50% eudragit S100, 30% compritol 888 ATO and 15% HPMC E50 showed good balance between buoyancy and prolonged drug release over 12 hours....
The objective of this work was to develop sustained release formulation of famotidine by using polymers (guar gum and hupu gum). Six formulations of sustained release matrix granules were prepared by wet granulation method, in the ratios of (1:1, 1:1.5, 1:2). The prepared granules were evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. 50 mg of famotidine granules were accurately weighed and these granules are filled in to capsules. These capsules are hard gelatin capsule shells, are made up of gelatin, sugar and water. Generally, they are clear, colorless and tasteless. Gelatin is the main material of these capsules due to its excellent characteristic as a gelatinizer. In-vitro studies revealed that famotidine formulation with hupu gum was able to sustain the drug release for 8 hours (95.1±0.83). Fitting the in-vitro release data to kinetic analysis, the best fit release kinetics was achieved in peppas and zero order. Results of the present study indicated that famotidine capsules filled with matrix granules can be delivered successfully as sustained release formulation....
The objective of the present study was the formulation and characterization of floating drug delivery system of tolperisone hydrochloride, which would remain in stomach and/or upper part of GIT for prolonged period of time. The floating tablets of tolperisone hydrochloride were prepared by direct compression method using various polymers like HPMC K100M and PEO N12K were used in various concentrations. The formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time, % CDR etc. From the results obtained, batch F10 showed the lowest lag time of 32.27±1.89 sec and the highest % CDR of 86.46±1.22. Tolperisone Hydrochloride was formulated as floating tablets to give sustained effect using various polymers and crosspovidone used as matrix ballooning inducer. From the results obtained, it was found that concentration of polymer and crosspovidone played important role in achieving desired lag time, floating time and % CDR of the formulated tablets. Hence the optimum concentration of HPMC K100M and crosspovidone were required to formulate floating tablets to increase GRT. From the results obtained, it was concluded that the optimized formulation containing HPMC K100M and crosspovidone shows better swelling properties with desired drug release properties and floating behaviour. Hence HPMC K100M is a potential polymer candidate for formulation of sustained release floating non effervescent tablets....
Cefuroxime Axetil (CA) is a broad spectrum cephalosporin. The literature survey reveals that its intake causes diarrhoea. The objective of the present study was to address challenges in research and development associated with its bitter taste and poor aqueous solubility. The inclusion complex of CA-HPβCD was prepared in molar ratio of 1:1. Banana starch was added as natural antidiarrheal agent to CA-HPβCD inclusion complex and taste masking followed by direct compression as MDTs at 150 psi compression pressure. Bitter taste threshold, DSC, PXRD, saturation solubility, in-vitro dissolution studies were carried out for pure drug CA, commercial tablet CEFTUM and prepared CA MDTs. The central composite factorial design with two factors was adopted to optimize the responses namely disintegration time and 75% drug release. Formulation F7 was selected as optimized batch that was subjected to accelerated stability studies at 40C±2C/75% ±5% RH for 3months as per ICH guidelines. The results demonstrated that the combination of CA-HPβCD inclusion complex and banana starch can efficiently act as antidiarrheal agent and mask the bitter taste of CA and significantly enhance its aqueous solubility and possess improved physical stability with comparable solubility and dissolution profile....
Lamotrigine is BCS class II drug; hence dissolution is rate-limiting step in its absorption. Oral bioavailability of lamotrigine was improved using inclusion complex formation technique. LMG and HP-β-CD (1:3) was selected as optimized ratio for formation of complex. This complex was formulated into fast dissolving tablet. For preparation of fast dissolving tablet nine formulas were designed using 3² factorial design in which soya polysaccharide and indion 414 were used as superdisintegrants in varying concentration. The effect of types and concentrations of superdisintegrant on the disintegration time and dissolution profile of lamotrigine fast dissolving tablets were studied. The % drug release of fast dissolving tablet prepared using F7 has shown 99.33 % drug release after 6 minutes which was comparable with marketed formulation....
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